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On April 1, 2026, the FDA approved orforglirpon under the brand name Foundayo to reduce excess body weight and maintain weight reduction long term in: Adults with obesity Adults with overweight and at least one weight-related medical condition Like other GLP-1s for weight loss, orforglipron is also indicated in combination with a reduced-calorie diet and increased physical activity

This is why weight loss is best understood as a downstream effect rather than the first measurable change

Semaglutide and tirzepatide are currently the most effective options for weight loss, with once-weekly dosing and strong clinical results

1 Clinical evidence STEP 8: semaglutide vs liraglutide head-to-head The STEP 8 trial published in JAMA is the only head-to-head comparison of semaglutide and liraglutide for weight loss

Your provider takes these preferences into account alongside the clinical factors

Depends on the research question